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Research Tech I- Ya-Ming Hou Lab - Biochemistry & Molecular Biology, Philadelphia, Pennsylvania

Created 07/21/2021
Reference 9254338
Category Research
Job type Full Time
Country United States
State Pennsylvania
City Philadelphia
Zip 19019
Salary Competitive
A research technician position is available with Professor Ya-Ming Hou at Thomas Jefferson University, Philadelphia. We focus on tRNA and explore how its epigenetic changes control gene expression at the frontier of molecular biology and the central dogma. We use a synthetic biology approach with CRISPR-edited genomes to investigate the mechanism of changes using enzyme- and cell-based assays.

Current projects on tRNA epigenetic biology include:
  • Bacterial existing from sleep
  • Multidrug resistance to antibiotics
  • Suppressors of loss of essential genes
  • Ribosome translation encountering epigenetic modifications in tRNA and mRNA

For more information, please see the following publications and our website:

Nat Communications (2021). PMID: 33436566

Cell Chem Biol (2020). PMID: 32553119

ACS Catal (2020). PMID: 32904895 (Featured as the cover)

Ann Neurol (2020). PMID: 32715519

Cell Systems (2019). PMID: 30981730 (Featured in Faculty 1000 Prime)

PNAS (2016). PMID: 27849575 (Featured in PNAS commentary)

Nat Struct Mol Biol (2016). PMID: 27571175 . (Featured in Science)

Nature Communications (2015). PMID: 26009254

Chem and Biol ( Cell Press) (2014). PMID: 25219964

Nature (2014). PMID: 24919148 (Featured in Nature News and Views)




Requirements of candidates:
  • A recent bachelor's degree
  • Research experience in molecular biology or genetics
  • Aspiration to pursue a MS or PhD degree in biochemistry and molecular biology

Closing Statement

Jefferson Health delivers state of the art healthcare services to patients throughout the Delaware Valley and southern New Jersey. Jefferson (Philadelphia University + Thomas Jefferson University) provides more than 8,400 students from nearly 40 states and 40 countries with 21st century professional education. Combined, we have over 30,000 employees.

Jefferson Health, with 14 hospitals (seven are Magnet designated by the ANCC for nursing excellence) and 40+ outpatient and urgent care locations, offers a broad range of primary and complex, highly specialized care that touches the lives of more than four million patients annually. U.S. News & World Report has ranked Thomas Jefferson University Hospital among the nation's best in eight specialties. Jefferson Health also includes the NCI designated Sidney Kimmel Cancer Center; it is one of only 70 such centers in the nation.

Thomas Jefferson University has ten colleges and three schools that offer more than 160 undergraduate and graduate programs. Our University is dedicated to inter-professional and transdisciplinary approaches to learning that offer a vibrant and expandable platform for professional education. Through this unique model, we are preparing our students for current and yet to be imagined careers.

As an employer, Jefferson maintains a commitment to provide equal access to employment. Jefferson values diversity and encourages applications from women, members of minority groups, LGBTQ individuals, disabled individuals, and veterans.
Employer Abington Hospital - Jefferson Health

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