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Senior Research Investigator - Department of Biochemistry and Molecular Biology - Lab of Dr. Dmit..., Philadelphia, Pennsylvania

Created 06/11/2021
Reference 9252875
Category Research
Job type Full Time
Country United States
State Pennsylvania
City Philadelphia
Zip 19019
Salary Competitive
Senior Research Investigator - structural studies of mitochondrial gene expression

An NIH funded position is immediately available in the laboratory of Dr. Dmitry Temiakov in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University to study mechanisms of human mitochondrial gene expression (Hillen et al, Cell 2017, 171(5)1082 ; Agaronyan et al., Science 2015, 347:6221, Ringel et al., Nature 2011, 478: 269). Dr. Temiakov's laboratory is using biochemical and structural methods to study mitochondrial transcription and replication. The laboratory is located in a newly renovated space and has access to core resources for bioimaging, cancer research and structural biology. The Structural Biology Core Facility has recently acquired Thermo Scientific™ Glacios™ Cryo-Transmission Electron Microscope equipped with Falcon 4 Direct Electron Detector. The laboratory has access to Krios TEM via NIH facilities.

We seek to hire a structural biologist with a demonstrated experience in X-ray crystallography and single particle cryoEM. Knowledge of the image processing software such as Relion, cryoSPARC, and crYOLO is required. Essential duties will include preparation of samples for CryoEM, data collection and image processing, model building and structure refinement. The successful candidate will join an interactive environment with multiple laboratories investigating important aspects of mitochondrial biology.


MD or Ph.D.in Biology, Biomedical Sciences or related field required. 5 plus years of lab management experience required. Experienced researcher with strong technical, analytical, management, organizational, communication, writing and interpersonal skills. Must have a solid base knowledge of advanced scientific principals and methods. Familiarity with a wide range of laboratory equipment.

Closing Statement

Jefferson Health delivers state of the art healthcare services to patients throughout the Delaware Valley and southern New Jersey. Jefferson (Philadelphia University + Thomas Jefferson University) provides more than 8,400 students from nearly 40 states and 40 countries with 21st century professional education. Combined, we have over 30,000 employees.

Jefferson Health, with 14 hospitals (seven are Magnet designated by the ANCC for nursing excellence) and 40+ outpatient and urgent care locations, offers a broad range of primary and complex, highly specialized care that touches the lives of more than four million patients annually. U.S. News & World Report has ranked Thomas Jefferson University Hospital among the nation's best in eight specialties. Jefferson Health also includes the NCI designated Sidney Kimmel Cancer Center; it is one of only 70 such centers in the nation.

Thomas Jefferson University has ten colleges and three schools that offer more than 160 undergraduate and graduate programs. Our University is dedicated to inter-professional and transdisciplinary approaches to learning that offer a vibrant and expandable platform for professional education. Through this unique model, we are preparing our students for current and yet to be imagined careers.

As an employer, Jefferson maintains a commitment to provide equal access to employment. Jefferson values diversity and encourages applications from women, members of minority groups, LGBTQ individuals, disabled individuals, and veterans.
Employer Abington Hospital - Jefferson Health

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